Olfactory identification deficits at identification as ultra-high risk for psychosis are associated with poor functional outcome

A Lin; WJ Brewer; AR Yung; B Nelson; C Pantelis; SJ Wood

Journal article

Olfactory identification deficits at identification as ultra-high risk for psychosis are associated with poor functional outcome

A Lin, WJ Brewer, AR Yung, B Nelson, C Pantelis, SJ Wood

Schizophrenia Research | Published : 2015

DOI: 10.1016/j.schres.2014.10.051

Abstract

Background: We have previously reported that olfactory identification (OI) deficits are a promising premorbid marker of transition from ultra-high risk (UHR) to schizophrenia, but not to psychotic illness more generally. Whether this remains the case at longer follow-up, and whether there is decline in OI ability are unclear. Method: The University of Pennsylvania Smell Identification Test (UPSIT) was administered to 81 participants at baseline (identification of risk for psychosis) and 254 individuals at follow-up. Forty-nine participants underwent UPSIT assessment at both time points. UPSIT scores were investigated at an average of 7.08. years after identification of risk in relation to tr..

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University of Melbourne Researchers

Barnaby Nelson Author

Christos Pantelis Author

Stephen Wood Author

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Grants

Funding Acknowledgements

This work was supported by NHMRC Program Grants (# 350241 and 566529) and the Colonial Foundation, Australia. SJW and WJB were supported by the National Health and Medical Research Council (NHMRC) Career Development Awards. BN was supported by a Ronald Phillip Griffith Fellowship and a NARSAD Young Investigator Award. CP and ARY are the recipients of NHMRC Senior Principal and Senior Research Fellowships, respectively.